The CBC program tends to make the balloons really big and while you can resize them, the print usually doesn't fill up the balloons as well as a comic book. MAYBE TG knows how to get around it, but I find there's a lot of empty space. I haven't done any dialogue work lately. But I use Comic Sans for the usual voice at, iirc, Size8. Don't quote me on that cuz it could be 10-12 too. I try to make the balloons and print small so it doesn't detract too much from the picture. Course, I tend to be very wordy too...

Depending on the character, I WILL change fonts. I tend to use CHILLER for a doof like Overkill. When I did the S6 adventures, Cobra Commander used CHILLER also. I love that font but it's hard to read when small.

For effects, I use different fonts. Whatever looks decent. And I always BOLD the text.